Global Forum Perspectives: Evidence-Based Strategies for the Containment of Antibiotic Resistance

5 Oct 2011
Authors:

Sabiha Essack, (B. Pharm., M. Pharm., PhD), Professor in Pharmacy at the University of KwaZulu-Natal, is a Wellcome Trust Research Fellow who completed research towards her PhD in Pharmaceutical Microbiology in the UK.  She is speaking at the Global Forum on Using Surveillance Data to Best Inform Practice.  She is a member of the GARP-South Africa Working Group.

Antimicrobial resistance is currently the greatest challenge to the effective treatment of infections globally.  Resistance adversely affects both clinical and financial therapeutic outcomes with effects ranging from the failure of an individual patient to respond to therapy and the need for expensive and/or toxic alternative drugs to the social costs of higher morbidity and mortality rates, longer durations of hospitalisation, increased health care costs and the need for changes in empirical therapy.  Resistance may emerge by selection pressure (overuse/indiscriminate antimicrobial use in developed vs underuse/misuse in developing countries) but is perpetuated by diverse risk factors and maintained within environments as a result of poor infection control.   Population-specific drug pharmacokinetics and pharmacodynamics also play a role.  

Infection rates are conspicuously higher amongst impoverished populations largely in informal settlements in South Africa.  Poverty indicators such as inadequate hygiene and sanitation and limited access to energy, clean water and healthcare are classical risk factors for infections.  In addition, the large number of people already afflicted with HIV/AIDS is a prominent factor demonstrating an ever-increasing incidence and prevalence of infections. The vast majority of individuals plagued by poverty and HIV/AIDS are dependent on the public health system wherein a recent surveillance study exposed high levels of antibiotic resistance.  Risk factors unique to South African communities (poverty-associated factors, HIV and AIDS) and hospitals (duration of hospitalisation, location within the hospital, intensive care unit stay, surgery, wounds, previous and current antimicrobial therapy, mechanical ventilation, urinary catheterisation, nasogastric intubation, central venous and peripheral catheters, previous hospitalisation and transfer from another unit or hospital) must be determined and due vigilance exercised in patients exhibiting classical risk factors for the acquisition of or colonisation with resistant pathogens. Hygiene and sanitation (in communities) and infection control (in hospitals) status must be determined and interventions initiated to prevent the spread of resistance.  Pharmacokinetics and pharmacodynamics specific to diverse populations must be devised to optimise antimicrobial therapy. 

Several countries have initiated strategies for the containment of resistance, with surveillance critical to all.  Surveillance should be disease-based, establishing sensitivity profiles of common causative organisms to inform the development of or amendment to standard treatment guidelines and essential drugs lists adopted within national drug policies in developing countries globally.  Additionally, the manner of antimicrobial use (overuse, underuse, inadequate dosing) associated with resistance must be established for appropriate intervention to encourage rational drug use, a reduction in use and dosing regimens based on population-specific pharmacokinetics and pharmacodynamics. 

Evidence-based treatment of infections guided by local susceptibility/resistance would ensure productive, economically viable individuals capable of fulfilling their social roles.  Efficacious treatment would assure sustainable livelihoods in all populations (healthy and otherwise) as infections are the most frequently encountered health problem even in the absence of HIV/AIDS.  While one infection will ultimately be fatal, the efficacious use of antibiotics will successfully treat several infections in the lifetime of the AIDS patient even in the presence of a compromised immune system sustaining the economic viability of the country and limiting the economic collapse predicted by the World Bank. 

South Africa has unique needs in the antimicrobial resistance arena, needs to be addressed in the context of financial, human resources and technological challenges.