Are the seasonal fluoroquinolone usage patterns related to the timing of the influenza seasons and what proportion of use is associated with influenza activity?
A contemporaneous relationship between seasonal influenza activity and antibiotic use was determined. Specifically, respiratory fluoroquinolone increases during the same month that influenza activity increases.
Fluoroquinolone cannot treat viral infections. A significant proportion of the increase of antimicrobial usage during influenza season is probably unnecessary and probably contributes to antimicrobial resistance.
We show that respiratory fluoroquinolone use is extremely seasonal and that fluoroquinolone use is strongly associated with influenza. In our time series model, instantaneous influenza activity was a significant predictor of use ([Formula: see text]). Also, we estimated that reducing influenza activity by 20% would reduce prescriptions by 8%.

